Warehouse worker, Amazon
She headed to the Senate to blast her employer for its “grueling” working conditions, sharing her struggles working for the e-commerce behemoth. Her testimony drew national attention to a landmark Amazon union drive in Alabama, and to her own life story.
She inherited a bank languishing in third place, hobbled by internal failures and PR embarrassments. Rather than cracking the whip she’s proposing hybrid work, Zoom-free Fridays and a radical idea on Wall Street: Ruthlessness doesn’t have to define culture.
General Counsel, Twitter
She spearheaded what was arguably Twitter’s riskiest decision: banning its most powerful user, Donald Trump. And now she’s on the other side, facing down heads of state that are banning — or threatening to ban — Twitter itself.
Chef & Owner, Eleven Madison Park
He soared to culinary stardom on dishes like lavender-honey glazed duck, butter-poached lobster and a famous foie gras. Now he’s going vegan: leaving meat off the menu at his lavish eatery Eleven Madison Park and trying to make a mark with vegetables alone.
General Manager, Miami Marlins
She was Derek Jeter’s first call when he needed someone to turn the Marlins around. Not only is she Major League Baseball’s first female GM, but she’s tasked with reviving a team with a small budget, limited payroll and frustrated fanbase.
CEO, Serum Institute of India
His massive vaccine company manufactured millions of Covid-19 jabs last year, even before they were approved. But it wasn’t enough after India’s brutal second wave. The “vaccine prince” needs to get back on track to stop vaccine inequality — and the pandemic.
He axed hundreds of well-known brands, including the beloved Odwalla and Tab. Then he turned to Coke. In the US he killed Coca-Cola Energy, a much-hyped beverage that was fairly new, and he changed the Coca-Cola Zero Sugar recipe. Will the ruthless strategy pay off?
His company makes eye-poppingly fast electric hypercars in Croatia, and it’s now taking over the storied Bugatti brand. He’s betting he can steer the maker of gas-guzzling supercars through the treacherous turn to electrification.
He built Didi into a world-class ride-hailing app and elbowed Uber out of China. But then he incurred Beijing’s wrath by going public in the US. Now he faces a balancing act: placating both regulators at home and investors abroad.
CEO, ARK Invest
She’s one of Wall Street’s most influential fund managers, making huge bets on future-focused companies like Tesla, Coinbase and Teladoc. But this high-risk/high-reward investing has put her investors on a white-knuckle ride in 2021.
Lead video producer
Logan Whiteside, Sean Clark, Frank Fenimore, Janelle Gonzalez, Channon Hodge, Tawanda Scott
Chris Sessions/RWDSU, Kyle Grillot/Bloomberg/Getty Images, David Paul Morris/Bloomberg/Getty Images, Bryan Steffy/Getty Images for Keep Memory Alive, Michael Reaves/Getty Images, Dhiraj Singh/Bloomberg/Getty Images, Simon Dawson/Bloomberg/Getty Images, Petar Santini/Bloomberg/Getty Images, Hou Yu/China News Service/Getty Images, Courtesy ARK Investment Management